Ultra Pure UDP-Sugar Substrates

UDP-GlcNAc, UDP-GalNAc, UDP-Glucose, UDP-Galactose and UDP-Glucuronic Acid are ultra-pure UDP-sugar substrates designed for use with the UDP-Glo™ Glycosyltransferase Assay—a bioluminescent assay for detecting the activity of glycosyltransferases that use UDP-sugars as donor substrates.

Glycosylation reactions catalyzed by glycosyltransferases are central to many biological processes, including cell:cell interactions, cell signaling and bacterial cell wall biosynthesis. Glycosyltransferases transfer sugar from a nucleotide-glycosyl donor (e.g., UDP-Galactose, UDP-Glucose, UDP-GlcNAc, UDP-GalNAc and UDP-Glucuronic Acid) to an acceptor molecule. In a glycosyltransferase reaction, the UDP moiety is released as a product; therefore, an assay that detects UDP can be used to monitor the activity of the majority of glycosyltransferases.